Splice-station-sidebar-header
No-podcasts
Ad
 
14
May
2009
24:14 mins
Episode: MTS27 - Melanie Cushion - Pneumocystis carinii 
MicrobeWorld's Meet the Scientist Podcast | 118 Episodes
Liked it:
---
<p>Melanie Cushion holds down two jobs: she&rsquo;s a research career scientist at the Veterans Administration Medical Center in Cincinnati, Ohio, and she&rsquo;s also professor and associate chair for research in the department of internal medicine at the University of Cincinnati College of Medicine.&nbsp; Dr. Cushion focuses her research on the fungus, Pneumocystis carinii, which is a harmless commensal for most people, but a deadly pathogen for others.&nbsp; <br /> <br /> Pneumocystis carinii was shrouded in obscurity for many years until its fifteen minutes in the spotlight came in the 80&rsquo;s, when, unfortunately, an outbreak of Pneumocystis pneumonia prefigured the AIDS epidemic.&nbsp; Large numbers of previously healthy homosexual men in California became deathly ill with Pneumocystis pneumonia, and doctors knew something unusual (later found to be HIV) was going on.&nbsp; Dr. Cushion says Pneumocystis pneumonia is an opportunistic infection: it strikes individuals with immune systems too weak to fend it off.&nbsp; This explains why it was &ndash; and still is &ndash; a well-known sign that the patient is stricken with an active HIV infection or some other immune-suppressing disorder.&nbsp; <br /> <br /> Dr. Cushion heads up the Pneumocystis genome project and she&rsquo;s also looking into a new line of drugs called glucan synthase inhibitors, which have a profound effect on Pneumocystis&rsquo;s life cycle and may offer new insights into managing the pathogen.<br /> <br /> In this interview, I talked with Dr. Cushion about some of the more surprising results to come out of her genomics work, why Pneumocystis is a tough nut to crack in the laboratory, and about why she&rsquo;s not giving her young investigator award back to the Society of Protozoologists any time soon.</p><div class="feedflare">
<a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:yIl2AUoC8zA"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?d=yIl2AUoC8zA" border="0" /></a> <a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:F7zBnMyn0Lo"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?i=k7ZB6MHARxo:g7XCpcq6eVE:F7zBnMyn0Lo" border="0" /></a> <a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:V_sGLiPBpWU"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?i=k7ZB6MHARxo:g7XCpcq6eVE:V_sGLiPBpWU" border="0" /></a> <a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:qj6IDK7rITs"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?d=qj6IDK7rITs" border="0" /></a> <a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:gIN9vFwOqvQ"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?i=k7ZB6MHARxo:g7XCpcq6eVE:gIN9vFwOqvQ" border="0" /></a> <a href="http://feeds.feedburner.com/~ff/MicrobeWorld?a=k7ZB6MHARxo:g7XCpcq6eVE:oBgE7isVTB0"><img src="http://feeds.feedburner.com/~ff/MicrobeWorld?d=oBgE7isVTB0" border="0" /></a>
</div><img src="http://feeds.feedburner.com/~r/MicrobeWorld/~4/k7ZB6MHARxo" height="1" width="1" />
Link to this Episode
Promote this show on your site
Dailysplice_badge
 

 
Add Your Comment:
simple_captcha.jpg
(type the code from the image)
Please wait...